Wordpress MU is for blog hosts, IMO. I wouldn't use it for anything else. It is a little less secure because you have multiple people basically sharing the same database. If you were to open a blogging service, then yes, MU is for you.
If you just want to open multiple blogs, I would consider multiple intalls of single user WP. Yes it's a bit more of a hassle, but in the long run it is more secure (as long as you use different credentials for each, and different credentials for each DB)
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